发明名称 |
POLYMERIC DRUG DELIVERY CONJUGATES AND METHODS OF MAKING AND USING THEREOF |
摘要 |
Described herein are biodegradable drug delivery conjugates for effectively delivering bioactive agents to a subject. The drug delivery conjugates comprise a water-soluble high molecular weight linear biodegradable polymer backbone comprising a plurality of linear water-soluble polymeric segments connected to one another by a first (main-chain) cleavable linker, wherein a bioactive agent is covalently bonded to at least one water-soluble polymeric segment, at least one cleavable linker, or a combination thereof. The conjugates possess numerous advantages over prior art delivery conjugates. Also described herein are methods for making and using the conjugates. |
申请公布号 |
EP2544701(A2) |
申请公布日期 |
2013.01.16 |
申请号 |
EP20110753858 |
申请日期 |
2011.03.07 |
申请人 |
UNIVERSITY OF UTAH RESEARCH FOUNDATION |
发明人 |
PAN, HUAIZHONG;KOPECKOVA, PAVLA;YANG, JIYUAN;KOPECEK, JINDRICH;LUO, KUI. |
分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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