发明名称 |
Radiopaque, non-biodegradable, water-insoluble iodinated benzyl ethers of poly(vinyl alcohol), preparation method thereof, injectable embolizing compositions containing thereof and use thereof |
摘要 |
The invention concerns a radiopaque, non-biodegradable, water-insoluble iodinated benzyl ether of poly(vinyl alcohol) consisting of a PVA having covalently grafted thereon iodinated benzyl groups comprising 1 - 4 iodine atoms per benzyl group, a process for preparing the same comprising reacting a 0 - 100 % hydrolyzed PVA with a iodinated benzyl derivative comprising 1 - 4 iodine atoms per benzyl group in a polar aprotic solvent in the presence of a base in anhydrous conditions. Said iodo-benzylether-PVA is useful as embolic agent in an injectable embolizing composition. The invention also concerns an injectable embolizing composition comprising the iodo-benzylether-PVA and a water-miscible, biocompatible solvent solubilizing the iodo-benzylether-PVA, wherein the concentration of the iodo-benzylether-PVA in the composition is selected in the range of 5 - 65 w/w % so that the composition is capable of forming a cohesive mass upon contact with a body fluid by precipitation of the iodo-benzylether-PVA. Said injectable embolizing composition is particularly useful for forming in-situ a cohesive mass in a blood vessel or into a tumor |
申请公布号 |
EP2545085(A1) |
申请公布日期 |
2013.01.16 |
申请号 |
EP20110707664 |
申请日期 |
2011.03.09 |
申请人 |
UNIVERSITE CLAUDE BERNARD LYON 1 (UCBL);CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;ANTIA THERAPEUTICS S.A. |
发明人 |
CHEVALIER, YVES;AGUSTI, GERALDINE;NYFFENEGGER, CORALIE;DOELKER, ERIC;JORDAN, OLIVIER;ANDERSEN, GERT |
分类号 |
C08F8/18;A61K49/04;A61L24/00;A61L31/10;C09D129/04 |
主分类号 |
C08F8/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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