发明名称 |
KINETIC RESOLUTION OF (4S)-4-PHENYL-3-[5(RS)-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-1,3 OXAZOLIDIN 2-ONE TO (5S) ISOMER VIA LIPASE CATALYZED ENANTIOSELECTIVE ESTERIFICATION OF THE (5R) ISOMER |
摘要 |
<p>A process for synthesis of 4S-phenyl-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-1,3 oxazolidin 2-one comprising resolution of 4S-phenyl-3-[(5RS)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-1,3 oxazolidin 2-one by selective esterification of 4S-phenyl-3-[(5R)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-1,3 oxazolidin 2-one using appropriate esterification reagent in an organic solvent in presence of Lipase enzyme at a temperature ranging from 0° to 100° C., and further isolation.</p> |
申请公布号 |
EP2414339(B1) |
申请公布日期 |
2013.01.16 |
申请号 |
EP20100714487 |
申请日期 |
2010.04.05 |
申请人 |
LUPIN LTD. |
发明人 |
LATHI, PIYUSH, SURESH;ROY, BHAIRAB, NATH;SINGH, GIRIJ, PAL;SHRIVASTAVA, DHANANJAI |
分类号 |
C07D263/22 |
主分类号 |
C07D263/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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