发明名称 |
CYANOCOBALAMIN LOW VISCOSITY AQUEOUS FORMULATIONS FOR INTRANASAL DELIVERY |
摘要 |
A stable pharmaceutical aqueous solution of cyanocobalamin comprised of cyanocobalamin and water wherein said solution of cyanocobalamin is suitable for intranasal administration, has a viscosity less than about 1000 cPs, and yields a bioavailability of cyanocobalamin when administered intranasally of at least about 5% relative to an intramuscular injection of cyanocobalamin. The present invention is also directed towards a method for elevating the vitamin B 12 levels in the cerebral spinal fluid (CSF) comprising administering intranasally a sufficient amount of a cyanocobalamin solution so as to increase the average ratio of vitamin B 12 in the CSF to that in the blood serum (B12 CSF/B12 Serum x 100) to at least about 1.1 comprising intranasally administering an aqueous solution of a cyanocobalamin, wherein said solution of cyanocobalamin has a bioavailability of at least 5% relative to an intramuscular injection of a cyanocobalamin. |
申请公布号 |
EP2035441(A4) |
申请公布日期 |
2013.01.16 |
申请号 |
EP20060785533 |
申请日期 |
2006.06.23 |
申请人 |
PAR PHARMACEUTICAL, INC. |
发明人 |
QUAY, STEVEN, C.;GO, ZENAIDA, O.;APRILE, PETER, C.;SILENO, ANTONY, P. |
分类号 |
A61K31/714;A61K9/08;A61K47/10 |
主分类号 |
A61K31/714 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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