发明名称 |
METHOD FOR AMPLIFICATION OF HEMATOPOIETIC STEM CELL USING HETEROCYCLIC COMPOUND |
摘要 |
An object of the present invention is to expand CD34 + cells ex vivo efficiently in a short term using a biologically safe and inexpensively obtainable low molecular weight compound. A still another object of the present invention is to provide an expansion agent for CD34 + cells useful for treatment of various hematopoietic disorders caused by dysfunctional hematopoietic stem cells and/or hematopoietic progenitor cells. A method for expanding CD34 + cells, which comprises culturing CD34 + cells ex vivo in the presence of a compound represented by the formula (I) (wherein A, B, L 1 , L 2 , L 3 , L 4 , R 1 , R 2 , R 3 , X and Y are defined in the description), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof. |
申请公布号 |
EP2233561(A4) |
申请公布日期 |
2013.01.16 |
申请号 |
EP20080856980 |
申请日期 |
2008.12.05 |
申请人 |
NISSAN CHEMICAL INDUSTRIES, LTD. |
发明人 |
NAKAMURA, TAKANORI;MIYAMURA, ATSUSHI;NISHINO, TAITO;ISHIWATA, NORIHISA;MIYAJI, KATSUAKI |
分类号 |
C12N5/0789;A61P7/00;A61P7/06;A61P9/10;A61P19/08;A61P35/00;A61P35/02;A61P37/02 |
主分类号 |
C12N5/0789 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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