发明名称 |
OSMOTIC DEVICE CONTAINING AMANTADINE AND AN OSMOTIC SALT |
摘要 |
The osmotic devices of the present invention contain a unitary core comprising a salt of amantadine and an osmotic salt, wherein the two salts have an ion in common. The release rate of the amantadine is modified from a first order release profile to a zero order, pseudo--zero order or sigmoidal release profile by increasing the amount of the osmotic salt in the core of the device. The osmotic device includes a semipermeable membrane having a controlled porosity that can be adapted as needed to cooperate with the osmotic salt in providing a predetermined drug release profile. The osmotic salt need not be coated and it is in admixture with the amantadine salt.
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申请公布号 |
CA2589479(C) |
申请公布日期 |
2013.01.15 |
申请号 |
CA20052589479 |
申请日期 |
2005.12.02 |
申请人 |
OSMOTICA CORP. |
发明人 |
MEYER, GLENN A.;FELEDER, ETHEL C.;RICCI, MARCELO A.;COPPARI, MARCELO A.;BEFUMO, MARCELO E.;FAOUR, JOAQUINA;VERGEZ, JUAN A. |
分类号 |
A61K31/13;A61K9/20;A61K9/28 |
主分类号 |
A61K31/13 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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