发明名称 |
Cyclised alpha-conotoxin peptides |
摘要 |
This invention relates to an oral or enteral pharmaceutical preparation comprising at least one synthetically cyclised alpha-conotoxin peptide having an amide cyclised backbone such that the peptide has no free N- or C-terminus, said peptide having the ability to inhibit a nicotinic acetylcholine receptor and comprising four cysteine residues bonded in pairs to form two disulfide bonds, wherein the N-terminus of the corresponding linear/non-cyclised conotoxin peptide is linked to the C-terminus by a peptide linker, in a vehicle which is pharmaceutically suitable for oral or enteral administration.
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申请公布号 |
US8354372(B2) |
申请公布日期 |
2013.01.15 |
申请号 |
US20070297110 |
申请日期 |
2007.04.03 |
申请人 |
THE UNIVERSITY OF QUEENSLAND;CLARK RICHARD;CRAIK DAVID JAMES |
发明人 |
CLARK RICHARD;CRAIK DAVID JAMES |
分类号 |
A61K38/00;A61K38/12;A61K38/16;C07K5/00;C07K7/00;C07K16/00;C07K17/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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