发明名称 |
CONTROLLED RELEASE OXYCODONE COMPOSITIONS |
摘要 |
A method for preparing a solid oral dosage form comprising up to about 160 mg of oxycodone or a salt thereof to control pain in substantially all patients is disclosed. The method comprises wet granulating at least one hydrophilic or hydrophobic polymer, preferably a hydroxyalkyl cellulose or an alkyl cellulose, with oxycodone or a salt thereof to form a controlled-release matrix. Repeated q12h (i.e., every 12 hour) administration of the dosage form through steady-state conditions results in a mean maximum plasma concentration of oxycodone up to about 240 ng/ml from a mean of about 2 to about 4.5 hours after administration, and a mean minimum plasma concentration up to about 120 ng/ml from about 10 to about 14 hours after administration.
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申请公布号 |
US2013012533(A1) |
申请公布日期 |
2013.01.10 |
申请号 |
US201213604066 |
申请日期 |
2012.09.05 |
申请人 |
PURDUE PHARMA L.P.;PURDUE PHARMACEUTICALS L.P.;THE P.F. LABORATORIES, INC.;OSHLACK BENJAMIN;MINOGUE JOHN JOSEPH;CHASIN MARK;FRANCIS KAIKO ROBERT |
发明人 |
OSHLACK BENJAMIN;MINOGUE JOHN JOSEPH;CHASIN MARK;FRANCIS KAIKO ROBERT |
分类号 |
A61K31/485;A61P25/04 |
主分类号 |
A61K31/485 |
代理机构 |
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