发明名称 |
BIARYL DERIVATIVES AS NACHR MODULATORS |
摘要 |
Disclosed is a compound of formula (I): wherein 'D', ?', 'm', 'n' and R1-R4 are as described herein, as a modulator of nicotinic acetylcholine receptors particularly the a7 subtype, in a subject in need thereof, as well as analogues, prodrugs, isotopically substituted analogs, metabolites, pharmaceutically acceptable salts, polymorphs, solvates, isomers, clathrates, and co-crystal thereof, for use either alone or in combinations with suitable other medicaments, and pharmaceutical compositions containing such compounds and analogues. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and therapy of disorders such as Alzheimer's disease, mild cognitive impairment, senile dementia, and the like. |
申请公布号 |
WO2013005153(A1) |
申请公布日期 |
2013.01.10 |
申请号 |
WO2012IB53347 |
申请日期 |
2012.07.02 |
申请人 |
LUPIN LIMITED;SINHA, NEELIMA;KARCHE, NAVNATH, POPAT;HATNAPURE, GIRISH, DHANRAJ;HAJARE, ANIL, KASHIRAM;PALLE, VENKATA, P.;KAMBOJ, RAJENDER, KUMAR |
发明人 |
SINHA, NEELIMA;KARCHE, NAVNATH, POPAT;HATNAPURE, GIRISH, DHANRAJ;HAJARE, ANIL, KASHIRAM;PALLE, VENKATA, P.;KAMBOJ, RAJENDER, KUMAR |
分类号 |
C07D277/28;A61K31/381;A61K31/401;A61K31/4025;A61K31/426;C07D207/335;C07D277/30;C07D333/22 |
主分类号 |
C07D277/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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