发明名称 |
ANTI-KIT ANTIBODIES AND USES THEREOF |
摘要 |
Provided herein, in one aspect, are antibodies that immunospecifically bind to a human KIT antigen comprising the fourth and/or fifth extracellular Ig-like domains (that is, D4 and/or D5 domains), polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. The antibodies can inhibit KIT activity, such as ligand-induced receptor phosphorylation. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to a KIT antigen, as well as methods of treating or managing a KIT-mediated disorder or disease and methods of diagnosing a KIT-mediated disorder or disease using the antibodies described herein.
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申请公布号 |
US2013011406(A1) |
申请公布日期 |
2013.01.10 |
申请号 |
US201113637272 |
申请日期 |
2011.03.25 |
申请人 |
KOLLTAN PHARMACEUTICALS, INC.;HADARI YARON;RADKE SUSANNE;SCHLESSINGER JOSEPH;SUZUKI YOSHIHISA |
发明人 |
HADARI YARON;RADKE SUSANNE;SCHLESSINGER JOSEPH;SUZUKI YOSHIHISA |
分类号 |
A61K39/395;A61P29/00;A61P35/00;A61P35/02;C07K16/18;C12N1/13;C12N1/19;C12N1/21;C12N5/071;C12N5/10;C12N15/13;C12N15/63;G01N33/566 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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