发明名称 |
METHOD FOR ASSESSING THE ABILITY OF A PATIENT TO RESPOND TO OR BE SAFELY TREATED BY A NUCLEOSIDE ANALOG BASED-CHEMOTHERAPY |
摘要 |
The invention relates to an in vitro method for determining the ability of a patient with cancer to respond to a monochemotherapy or to a polychemotherapy involving the administration of at least one chemotherapeutic agent the liver elimination of which involves cytidine deaminase (CDA), or to be treated by at least one such chemotherapeutic agent, which method comprises determining the CDA activity in a biological sample of the patient, wherein a CDA activity above 6 U/mg of serum sample total protein is indicative of the inability of the patient to respond to the chemotherapy, a CDA activity between 1.1 U/mg and 6 U/mg of serum sample total protein is indicative of the ability of the patient to be treated by the chemotherapeutic agent when said agent is administered in the context of a monochemotherapy, and a CDA activity between 1.4 U/mg and 6 U/mg of serum sample total protein is indicative of the ability of the patient to be treated by the chemotherapeutic agent when said agent is administered in the context of a polychemotherapy.
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申请公布号 |
US2013011392(A1) |
申请公布日期 |
2013.01.10 |
申请号 |
US201013510705 |
申请日期 |
2010.11.19 |
申请人 |
ASSISTANCE PUBLIQUE HOPITAUX DE MARSEILLE;UNIVERSITE D'AIX MARSEILLE;CICCOLINI JOSEPH;MERCIER CEDRIC;SEITZ JEAN-FRANCOIS;DAHAN LAETITIA;ILIADIS ATHANASSIOS;OUAFIK L'HOUCINE |
发明人 |
CICCOLINI JOSEPH;MERCIER CEDRIC;SEITZ JEAN-FRANCOIS;DAHAN LAETITIA;ILIADIS ATHANASSIOS;OUAFIK L'HOUCINE |
分类号 |
C12Q1/34;A61K31/7068;A61K33/24;A61K39/395;A61P35/00 |
主分类号 |
C12Q1/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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