| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to compounds of general formulaand their pharmaceutically acceptable salts possessing the properties of TNF? inhibitor and IL-2 production stimulator, as well as to a pharmaceutical composition, a method of treating and a single standard dosage form and their use. In general formula, Y represents C=O or CH; and Rrepresents (C-C)alkyl substituted by (C-C)alkoxy group, 5-10-member aryl, (5-10-member aryl)-(C-C)alkyl, 5-10-member heterocyclyl, 5-10-member heterocyclyl-(C-C)alkyl, 5-10-member heteroaryl, (5-10-member heteroaryl)-(C-C)alkyl, (C-C)alkylcarbonyl, di(C-C)alkylaminocarbonyl, (C-C)alkoxycarbonyl, 5-10-member heteroarylcarbonyl or 5-10-member heterocyclylcarbonyl; wherein heterocyclyl contains 1-3 heteroatoms specified in N, S and O, and heteroaryl contains 1-3 heteroatoms specified in N, S and O and wherein Ris optionally substituted by one or more groups specified in (C-C)alkoxy, halo, (C-C)alkyl, carboxy, (C-C)alkylaminocarbonyl and (C-C)alkoxycarbonyl.EFFECT: preparing the pharmaceutically acceptable salts possessing the properties of TNF? inhibitor and IL-2 production stimulator.23 cl, 1 tbl, 24 ex |
