METHOD OF PRODUCING A NEBULISER COMPOSITION

摘要

The present invention relates to a method of producing a nebuliser composition, particularly a nebuliser composition suitable for nebulised pulmonary delivery to a patient. The method involves a) introducing a solid dosage form of the pharmaceutically active agent into a diluent; and b) dispersing and/or dissolving the pharmaceutically active agent in the diluent to form the nebuliser composition. Solid dosage forms of pharmaceutically active agents have been found to be surprisingly effective in the nebulised pulmonary delivery of the pharmaceutically active agent, especially where the solid dosage form is dispersed and/or dissolved in situ within a nebuliser and simultaneously nebulised to deliver the pharmaceutically active agent to the patient.