| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide methods for treating, preventing or ameliorating the symptoms of T cell-mediated immunological diseases, particularly autoimmune diseases, through the use of anti-CD3 antibodies. <P>SOLUTION: Administration of antibodies that specifically bind the epsilon subunit within a human CD3 complex is carried out. Such antibodies modulate the T cell receptor/alloantigen interaction and, thus, regulate the T cell mediated cytotoxicity associated with autoimmune disorders. Additionally, there are provided a modification method and modifier of the anti-CD3 antibodies such that they exhibit reduced or eliminated effector function and T cell activation as compared to non-modified anti-CD3 antibodies. <P>COPYRIGHT: (C)2013,JPO&INPIT |
