A PROCESS FOR PREPARATION OF ILOPERIDONE AND AMORPHOUS CO- PRECIPITATE OF ILOPERIDONE WITH PHARMACEUTICALLY ACCEPTABLE EXCIPIENT

摘要

A process for preparation of iloperidone wherein l-(4-(3-chloro- propoxy)-3-methoxyphenyl)ethanone is reacted with 6-fluo- ro-3-piperidin-4-yl-l,2 benzisoxazole hydrochloride in a biphasic solvent system in presence of an inorganic base and a phase transfer catalyst. Further, process for preparation of an amorphous co-precipitate of iloperidone or its acid addition salt along with pharmaceutically acceptable excipient is proposed. Further, the present invention also relates to a co-precipitate of amorphous form of iloperidone along with pharmaceutically acceptable excipients.