发明名称 Method of DNA sequencing by hybridisation
摘要 The present invention relates to a method for the determination of a nucleic acid sequence by physical manipulation. In particular, the said method comprises the steps of denaturing a double-stranded nucleic acid molecule corresponding to the said nucleic acid sequence by applying a physical force to the said molecule; and detecting a blockage of the renaturation of the double-stranded nucleic acid molecule. More specifically, the method comprises the steps of denaturing a double-stranded nucleic acid molecule corresponding to the said nucleic acid sequence by applying a physical force to the said molecule; providing a single- stranded nucleic acid molecule;renaturing the said double stranded nucleic acid molecule in the presence of the said single-stranded nucleic acid molecule; and detecting a blockage of the renaturation of the double-stranded nucleic acid.
申请公布号 AU2011257229(A1) 申请公布日期 2013.01.10
申请号 AU20110257229 申请日期 2011.05.26
申请人 CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);ECOLE NORMALE SUPERIEURE 发明人 BENSIMON, DAVID;ALLEMAND, JEAN-FRANCOIS;MANOSAS, MARIA;DING, FANG-YUAN;CROQUETTE, VINCENT
分类号 C12Q1/68 主分类号 C12Q1/68
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