发明名称 Process for the preparation of dronedarone
摘要 This invention relates to a process for the preparation of N-[2-n-butyl-3-{4-[(3- dibutylamino)-propoxy]-benzoyl} - 1-benzofuran-5-yl]-methane-sulfonamide of formula (I) and its pharmaceutically acceptable salts, according to one of the methylsulfonyl groups of the 2-n-butyl-3-[(di-n-butylamino-3-propoxy)-benzoyl]-5- bis-(methylsulfonamido)-benzofuran of formula (II) is selectively cleaved and if desired, the resulting compound of formula (I) is transformed into its salt.
申请公布号 AU2011266805(A1) 申请公布日期 2013.01.10
申请号 AU20110266805 申请日期 2011.06.10
申请人 SANOFI 发明人 FRIESZ, ANTAL
分类号 C07D307/80;A61K31/343;A61P9/00 主分类号 C07D307/80
代理机构 代理人
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