发明名称 |
AN ANTIBODY INDUCING ANTIGEN-SPECIFIC T CELL TOLERANCE AND USE THEREOF |
摘要 |
The present invention relates to an antibody binding to the domain 2 of human intercellular adhesion molecules-1 (ICAM-1) where the antibody is able to modulate the differentiation status of dendritic cells and induce antigen-specific T cell tolerance, thereby be effective in the prevention and/or treatment of T cell-mediated immune disorders such as transplantation rejection, graft-versus-host disease, and autoimmune disease. In addition, the present invention provides a pharmaceutical composition comprising the antibody, and method of using them for the treatment of disease. |
申请公布号 |
CA2844532(A1) |
申请公布日期 |
2013.01.10 |
申请号 |
CA20112844532 |
申请日期 |
2011.07.05 |
申请人 |
SNU R&DB FOUNDATION;DINONA INC. |
发明人 |
PARK, SEONG HOE;JUNG, KYEONG CHEON |
分类号 |
C07K16/28;A61K39/395;A61P37/00;C12N5/16 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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