发明名称 |
IMMUNOGLOBULIN AFFINITY LIGAND |
摘要 |
<p>Provided is affinity chromatography carrier for an immunoglobulin that simultaneously has high immunoglobulin-binding capability and chemical stability and that can be produced at low cost. An immunoglobulin-binding protein in which an amino acid substitution for not only maximizing the number of lysine residues on the protein surface of helix 3 and its peripherybut also minimizing the number of lysine residues present on the protein surfaces of helix 1 and helix 2 as immunoglobulin-binding regions and/or an amino acid substitution for eliminating an aspartic acid-proline sequence have (has) been carried out, or a multimer thereof, is used as an affinity ligand for an affinity chromatography carrier.</p> |
申请公布号 |
EP1992692(B1) |
申请公布日期 |
2013.01.09 |
申请号 |
EP20070714689 |
申请日期 |
2007.02.21 |
申请人 |
PROTENOVA CO., LTD. |
发明人 |
MAJIMA, EIJI;SHIMA, ATSUSHI;HARA, YUKO |
分类号 |
C07K1/22;C07K14/31;C07K16/00;C07K17/00;C12M1/00;C12N15/09;G01N30/88;G01N33/53;G01N37/00 |
主分类号 |
C07K1/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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