发明名称 |
PROCESS FOR THE PREPARATION OF ATAZANAVIR SULFATE SUBSTANTIALLY FREE OF DIASTEREOMERS |
摘要 |
<p>The present invention provides atazanavir sulfate substantially free of diastereomeric impurities. The present invention also provides atazanavir sulfate having D-tertiary leucine analogues less than 0.1%. The present invention further relates to an improved process for preparing atazanavir sulfate, substantially free of its diastereoisomeric impurities, which comprises of reacting diamino compound (IV) with N-methoxycarbonyl-(L)-tertiary-leucine (V) having D-isomer less than 0.1% to obtain atazanavir base; conversion of atazanavir base to atazanavir sulfate by reacting with sulfuric acid and crystallization of atazanavir sulfate from suitable organic solvent(s).</p> |
申请公布号 |
EP2542527(A2) |
申请公布日期 |
2013.01.09 |
申请号 |
EP20110711638 |
申请日期 |
2011.02.16 |
申请人 |
LUPIN LIMITED |
发明人 |
MAHAKAL, KUMODINI, KASHINATH;SINGH, GURVINDER, PAL;RAY, PURNA, CHANDRA |
分类号 |
C07D213/42 |
主分类号 |
C07D213/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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