发明名称 |
COMPOSITION FOR INHIBITING EXPRESSION OF TARGET GENE |
摘要 |
<p>An object of the present invention is to provide a composition for suppressing expression of a target gene, and the like. A composition comprising an RNA-encapsulated liposome, wherein the RNA contains a sequence consisting of 15 to 30 contiguous bases of a target gene mRNA (hereinafter, sequence X) and a base sequence (hereinafter, complementary sequence X') complementary to the sequence X, 1 to 90% of all sugars binding to the bases of the sequence X and the complementary sequence X' being ribose substituted by a modifying group at 2' position, and the liposome being capable of reaching a tissue or an organ containing an expression site of the target gene is provide.</p> |
申请公布号 |
EP2319519(A4) |
申请公布日期 |
2013.01.09 |
申请号 |
EP20090803053 |
申请日期 |
2009.07.31 |
申请人 |
KYOWA HAKKO KIRIN CO., LTD. |
发明人 |
YAGI, NOBUHIRO;ENOKIZONO, JUNICHI |
分类号 |
A61K31/712;A61K9/127;A61K31/7105;A61K31/713;A61K47/10;A61K47/18;A61K47/24;A61K47/28;A61K47/34;A61P29/00;A61P35/00;A61P43/00;C12N15/113 |
主分类号 |
A61K31/712 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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