发明名称 |
CRYSTALLINE FORMS FOR 5-AMINO-2,3-DIHYDROPHTHALAZINE-1,4-DIONE SODIUM SALT, PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME AND METHOD FOR THE PRODUCTION OF SAID FORMS |
摘要 |
<p>The invention relates to the provision of two novel crystalline forms I and II for 5-amino-2,3-dihydrophthalazine-1,4-dione sodium salt. Surprisingly, it was discovered that form I and form II have differing immunological effects. This advantageous property is useful for immunospecific applications. In addition, both forms have advantageous physicochemical properties, which are useful in the production, further processing and/or use of a pharmaceutical preparation of form I or form II or a mixture of both.</p> |
申请公布号 |
EP2542535(A1) |
申请公布日期 |
2013.01.09 |
申请号 |
EP20110710423 |
申请日期 |
2011.03.01 |
申请人 |
METRIOPHARM AG |
发明人 |
BREU, JOSEF;BRYSCH, WOLFGANG;KAISER, ASTRID;LUDESCHER, BEATE;MAASS, GERRIT;MARTIN, THOMAS;MILIUS, WOLFGANG;NIEDERMAIER, MICHAEL |
分类号 |
C07D237/32;A61K31/502;A61P37/02 |
主分类号 |
C07D237/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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