发明名称 |
MODULATION OF INTRACELLULAR SIGNALING |
摘要 |
<p>A method of treating a disease characterized by aberrant cell migration and/or invasion includes administering to a subject an effective amount of the peptide of SEQ ID NO:3, anÅ6 polypeptide, or an isolated polypeptide consisting essentially of the Link region of human CD44 as indicated in FIG. 17 to modulate a FAK signal transduction pathway for a sufficient period of time to treat the disease. A method of diagnosing a condition characterized by aberrant cell migration and/or invasion includes measuring the effect of these polypeptides on FAK signal transduction activity; wherein a change in FAK signal transduction activity is indicative of said aberrant cell migration or invasion. A method of diagnosing a condition characterized by aberrant cell migration and/or invasion includes imaging FAK signal transduction activity in the presence of these polypeptides.</p> |
申请公布号 |
EP2542253(A1) |
申请公布日期 |
2013.01.09 |
申请号 |
EP20110751401 |
申请日期 |
2011.03.04 |
申请人 |
ANGSTROM PHARMACEUTICALS, INC. |
发明人 |
FINLAYSON, MALCOLM;DAMAJ, BASSAM, B. |
分类号 |
A61K38/00;G01N33/48 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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