发明名称 |
Identification of a novel repressor on IFN-lambda promoter and siRNA against ZEB1 and BLIMP-1 to increase IFN-lambda gene activity |
摘要 |
The present invention is directed to the identification of a novel repressor located between ˜1.2 kb to ˜1.6 kb from the translation start site of the IFN-λ1 promoter. The present invention provides a method of using siRNAs against ZEB1 (binds to the repressor region) and BLIMP-1 (binds outside the repressor region) and increases the promoter activity of IFN-λ1 (i.e., increases the production of IFN-λ1 protein). siRNAs against ZEB1 mRNA or BLIMP-1 mRNA increase IFN-λ1 gene activity. There is provided a therapeutic application of siRNAs against ZEB1 and BLIMP-1 mRNAs in treating a mammal (including a human) by increasing the production of IFN-λ1 protein that promotes an anti-viral response as well as treats asthma diseases.
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申请公布号 |
US8349808(B2) |
申请公布日期 |
2013.01.08 |
申请号 |
US20100799925 |
申请日期 |
2010.05.05 |
申请人 |
MEDICAL DIAGNOSTIC LABORATORIES, LLC;GALLAGHER GRANT;SIEGEL RACHAEL;ESKDALE JOYCE |
发明人 |
GALLAGHER GRANT;SIEGEL RACHAEL;ESKDALE JOYCE |
分类号 |
A61K31/70;C07H21/02;C07H21/04;C12Q1/68 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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