发明名称 PENTENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC APPLICATIONS THEREOF
摘要 The invention relates to compounds of the formula (I): (see formula I) in which R1 represents a(C6-C18)aryl radical substituted by and/or fused to a saturated or unsaturated 5- to 8-membered monocyclic or polycyclic nucleus optionally containing one or more hetero atoms chosen from O, N and S, the said nucleus itself being optionally substituted; R2 and R3 are a hydrogen atom or a (C6-C18)aryl radical; and R is a hydrogen atom or a C1-C10 alkyl radical; to their use for the treatment of dyslipidaemia, atherosclerosis and diabetes, to pharmaceutical compositions comprising them and to the processes for the preparation of these compounds.
申请公布号 CA2566369(C) 申请公布日期 2013.01.08
申请号 CA20052566369 申请日期 2005.04.06
申请人 MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG 发明人 ZEILLER, JEAN JACQUES;DUMAS, HERVE;GUYARD-DANGREMONT, VALERIE;BERARD, ISABELLE;CONTARD, FRANCIS;GUERRIER, DANIEL;FERRAND, GERARD;BONHOMME, YVES
分类号 C07C59/68;A61K31/192;A61K31/222;A61K31/381;A61K31/426;C07C51/09;C07C67/343;C07C69/734;C07C69/736;C07D277/24;C07D333/16;C07D333/56 主分类号 C07C59/68
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