发明名称 |
Preparation of diazo and diazonium compounds |
摘要 |
A method for making diazo-compounds, diazonium salts thereof and other protected forms of these compounds. Diaz-compounds are prepared by reaction of a tertiary phosphine reagent carrying a reactive carbonyl group with an azide. The reaction can also generate an acyl triazene which can be converted thermally or by addition of base to form the diazo-compound or the acyl triazene can be isolated. The method is particularly useful for conversion of azides carrying one or more electron withdrawing groups to diazo-compounds. The method can be carried out in aqueous medium under mild conditions and is particularly useful for conversion of azido sugars to diazo-compound and diazonium salts thereof under physiological conditions. Tertiary phosphine reagents, particularly those that are water-soluble, and precursors for preparation of the reagents are provided.
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申请公布号 |
US8350014(B2) |
申请公布日期 |
2013.01.08 |
申请号 |
US20090620567 |
申请日期 |
2009.11.17 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION;RAINES RONALD THADDEUS;MYERS EDDIE LEONARD |
发明人 |
RAINES RONALD THADDEUS;MYERS EDDIE LEONARD |
分类号 |
C07C245/14;C07C245/20;C07C245/24 |
主分类号 |
C07C245/14 |
代理机构 |
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