发明名称 |
Soluble FMS-like tyrosine kinase-1 (sFLT-1) antibody and related composition, kit, methods of using, and materials and method for making |
摘要 |
An isolated antibody that specifically binds to sFlt-1 or a fragment thereof having (i) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO: 2, (ii) a variable light domain region comprising the amino acid sequence of SEQ ID NO: 4, or (iii) both (i) and (ii), a pharmaceutical composition and a kit comprising such an antibody, a method of making such an antibody, a method of determining the presence, amount or concentration of sFlt-1 or a fragment thereof in a test sample, a method of treating a patient in therapeutic or prophylactic need of an antagonist of sFlt-1, an isolated nucleic acid comprising a nucleotide sequence encoding the amino acid sequence of (i) SEQ ID NO: 2, (ii) SEQ ID NO: 4, or (iii) both (i) and (ii), optionally as part of a vector, and a host cell comprising and expressing such a nucleic acid.
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申请公布号 |
US8349325(B2) |
申请公布日期 |
2013.01.08 |
申请号 |
US20090643847 |
申请日期 |
2009.12.21 |
申请人 |
ABBOTT LABORATORIES;BROPHY SUSAN E.;DATWYLER SAUL A.;HAWKSWORTH DAVID J.;LAIRD DON C.;MANOJ SHARMILA;PUCCI DOMINICK L.;TIEMAN BRYAN C.;TYNER JOAN;TYNER, LEGAL REPRESENTATIVE LOWELL J.;YU ZHIGUANG |
发明人 |
BROPHY SUSAN E.;DATWYLER SAUL A.;HAWKSWORTH DAVID J.;LAIRD DON C.;MANOJ SHARMILA;PUCCI DOMINICK L.;TIEMAN BRYAN C.;TYNER JOAN;TYNER, LEGAL REPRESENTATIVE LOWELL J.;YU ZHIGUANG |
分类号 |
A61K39/395;C07K16/18;C07K16/28 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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