发明名称 |
THERAPEUTIC COMPOSITIONS AND METHODS FOR DELIVERY OF ACTIVE AGENTS CLEAVABLY LINKED TO NANOPARTICLES |
摘要 |
Various embodiments of the present invention pertain to therapeutic compositions that comprise: (1) an active agent (e.g., paclitaxel); and (2) a nanoparticle (e.g., gold nanoparticle). In such embodiments, the active agent is covalently linked to the nanoparticle through a cleavable linker (e.g., a linker containing a hydrazone species). Other embodiments of the present invention pertain to methods of treating a condition in a subject by administering the above-described therapeutic compositions to the subject.
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申请公布号 |
US2013004523(A1) |
申请公布日期 |
2013.01.03 |
申请号 |
US201013514847 |
申请日期 |
2010.12.09 |
申请人 |
WILLIAM MARSH RICE UNIVERSITY;ZUBAREV EUGENE;GIBSON JACOB |
发明人 |
ZUBAREV EUGENE;GIBSON JACOB |
分类号 |
A61K31/337;A61K39/395;A61P35/00;B82Y5/00;C07F1/12;C07K16/18;C08G65/08 |
主分类号 |
A61K31/337 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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