发明名称 |
SYSTEM AND METHOD FOR CONTROLLING FOCUSED ULTRASOUND TREATMENT |
摘要 |
A system and method for controlling the delivery of ultrasound energy to a subject is provided. In particular, such a system and method are capable of safely disrupting the blood-brain barrier. Ultrasound energy is delivered to produce cavitation of an ultrasound contrast agent at a selected pressure value. An acoustic signal is acquired following cavitation, from which a signal spectrum is produced. The signal spectrum is analyzed for the presence of harmonics, such as subharmonics or ultraharmonics. When subharmonics or ultraharmonics are present, the pressure value is decreased for subsequent sonications. If a previous sonication resulted in no subharmonics or ultraharmonics being generated, then the pressure value may be increased. In this manner, the blood-brain barrier can be advantageously disrupted while mitigating potentially injurious effects of the sonication. |
申请公布号 |
WO2013000091(A1) |
申请公布日期 |
2013.01.03 |
申请号 |
WO2012CA50445 |
申请日期 |
2012.06.29 |
申请人 |
SUNNYBROOK HEALTH SCIENCES CENTRE;O'REILLY, MEAGHAN ANNE;HYNYNEN, KULLERVO HENRIK |
发明人 |
O'REILLY, MEAGHAN ANNE;HYNYNEN, KULLERVO HENRIK |
分类号 |
A61N7/00 |
主分类号 |
A61N7/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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