发明名称 |
EXENDIN-4 ANALOGUE PEGYLATED WITH POLYETHYLENE GLYCOL OR DERIVATIVE THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF DIABETES CONTAINING THE SAME AS ACTIVE INGREDIENT |
摘要 |
The present invention relates to an exendin-4 analogue PEGylated with polyethylene glycol or a derivative thereof, a preparation method thereof, and a pharmaceutical composition for preventing or treating diabetes, containing the same as an active ingredient. According to the present invention, it is possible to increase the yield of a PEGylated exendin-4 analogue and to enhance the therapeutic effect of a drug through the selective PEGylation of cysteine using exendin-4 in which said cysteine (Cys) is introduced at position 40 of the C terminal, and thus it is possible to usefully employ the same in a composition for preventing or treating diseases caused by the hypersecretion of insulin. |
申请公布号 |
CA2839410(A1) |
申请公布日期 |
2013.01.03 |
申请号 |
CA20122839410 |
申请日期 |
2012.06.28 |
申请人 |
B&L DELIPHARM, CORP. |
发明人 |
LEE, SUNG KWON;KIM, WON BAE;LEE, SEULKI;KIM, TAE HYUNG |
分类号 |
A61K47/48;A61K38/22;A61K47/30;A61P3/10 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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