发明名称 |
CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS OF TAPENTADOL |
摘要 |
The present invention provides atazanavir sulfate substantially free of diastereomeric impurities. The present invention also provides atazanavir sulfate having D-tertiary leucine analogues less than 0.1%. The present invention further relates to an improved process for preparing atazanavir sulfate, substantially free of its diastereoisomeric impurities, which comprises of reacting diamino compound (IV) with N-methoxycarbonyl-(L)-tertiary-leucine (V) having D-isomer less than 0.1% to obtain atazanavir base; conversion of atazanavir base to atazanavir sulfate by reacting with sulfuric acid and crystallization of atazanavir sulfate from suitable organic solvent(s).
|
申请公布号 |
US2013005780(A1) |
申请公布日期 |
2013.01.03 |
申请号 |
US201113581981 |
申请日期 |
2011.02.16 |
申请人 |
LUPIN LIMITED;MAHAKAL KUMODINI KASHINATH;SINGH PAL;RAY PURNA CHANDRA |
发明人 |
MAHAKAL KUMODINI KASHINATH;SINGH PAL;RAY PURNA CHANDRA |
分类号 |
C07D213/53;A61K31/44;C07C227/40 |
主分类号 |
C07D213/53 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|