Described herein are pharmaceutical compositions according to aspects of the present invention which include one or more hydrophilic antineoplastic chemotherapeutics, such as vinca alkyloid antineoplastic chemotherapeutics, encapsulated in ceramide anionic liposomes. Methods of treatment of a subject having cancer using the pharmaceutical compositions are described, along with methods of making ceramide anionic liposomes which encapsulate one or more hydrophilic antineoplastic chemotherapeutics in the aqueous interior of the ceramide anionic liposomes.
申请公布号
WO2012154942(A3)
申请公布日期
2013.01.03
申请号
WO2012US37295
申请日期
2012.05.10
申请人
THE PENN STATE RESEARCH FOUNDATION;KESTER, MARK;SHANMUGAVELANDY, SRIRAM, S.;FOX, TODD