AN OPTIMIZED BILAYERED TABLET DOSAGE FORM WITH HIGH RATE OF BIOAVAILABILITY OF TWO ACTIVE ANTIBIOTICS: CEFUROXIME AND CLAVULANIC ACID

摘要

This invention discloses as both immediate release optimized pharmaceutical formulation for bilayer tablet form comprising at least one antibiotic or a pharmaceutically acceptable salt thereof, and at least one dissolution enhancing agent sufficient to substantially dissolve said one aqueous diluent, binder, disintigrants, Film forming agents, moisture barrier agents. The present invention pertains to the pharmaceutical bilayer tablet composition more preferably an oral administration of optimized, high bioavailability formulation of the active ingredient which typically is antibiotic Cefuroxime axetil and Clavulanic acid with the pharmaceutically accepted excipients by a novel way to formulate two or more active pharmaceutical ingredient in a single dosages form at same time with high solubility and stability by over coming cross interaction or chemical incompatibilities between two different physical, chemical and physicochemical drug molecules by physical separation, and to enable the development of different drug release profile both in immediate release and immediate release with extended release and promoting patient convenience and compliance.