VECTOR FOR THE RELEASE OF AN ACTIVE AGENT WHICH IS PHOTOCLEAVABLE BY IRRADIATION IN THE VISIBLE

摘要

A vector for the spatially and temporally controlled release of an active agent comprising nanoparticles of gold coated with a surfactant and an active agent bound to the said surfactant by means of a photocleavable bond, the said vector being capable of releasing the active agent when exposed to light radiation of wavelength greater than 400 nm included in the region of the visible or the region of the near infrared (NIR) through a multiple photon effect. In particular a vector in which the group having a photolabile bond is 1,2,3-triazole, which can for example be obtained by a click chemistry reaction between gold particles on the surface of which peptide molecules having a free carboxyl terminal group and an alkyne side group are chemiadsorbed and an azide of the active agent is described.