摘要 |
<p>There is provided compounds of formula I, wherein R1, R2, R3, R4, X, Y, Z and ring A have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. CDK8) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease.</p> |
申请人 |
CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO);PASTOR FERNANDEZ, JOAQUIN;ALVAREZ ESCOBAR, ROSA MARIA;VARELA BUSTO, CARMEN;GARCIA GARCIA, ANA BELEN;DIMITRIEVICH ZARICH, NATASHA;BLANCO APARICIO, CARMEN;RODRIGUEZ LOPEZ, ANA;OYARZABAL SANTAMARINA, JULEN;BISCHOFF, JAMES ROBERT |
发明人 |
PASTOR FERNANDEZ, JOAQUIN;ALVAREZ ESCOBAR, ROSA MARIA;VARELA BUSTO, CARMEN;GARCIA GARCIA, ANA BELEN;DIMITRIEVICH ZARICH, NATASHA;BLANCO APARICIO, CARMEN;RODRIGUEZ LOPEZ, ANA;OYARZABAL SANTAMARINA, JULEN;BISCHOFF, JAMES ROBERT |