METHODS FOR DESIGN OF EPITOPE SCAFFOLDS

摘要

Methods and apparatus for designing a functional protein scaffold are disclosed. A scaffold search is performed using a computing device. The scaffold search includes a search of a protein structure library for a native structure similar to a structure of a functional motif. The native structure can be supported by a protein scaffold. The native structure can be removed from the protein scaffold to create a protein sequence gap. The functional protein scaffold can be designed by inserting the functional motif into the sequence gap. The functional protein scaffold can be for targeting mAb b12.