MULTINOZZLE EMITTER ARRAYS FOR ULTRAHIGH-THROUGHPUT NANOELECTROSPRAY MASS SPECTROMETRY

摘要

The present invention provides for a structure comprising a plurality of emitters, wherein a first nozzle of a first emitter and a second nozzle of a second emitter emit in two directions that are not or essentially not in the same direction; wherein the walls of the nozzles and. the emitters form a monolithic whole. The present invention also provides for a structure comprising an emitter with a sharpened end from which the emitter emits; wherein the emitters forms a monolithic whole, 'The present invention also provides for a fully integrated separation of proteins and. small molecules on a silicon chip before the electrospray mass spectrometry analysis.