A NOVEL PROCESS FOR THE PREPARATION OF TAPENTADOL OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
摘要
Disclosed herein is a novel, commercially viable and industrially advantageous process for the preparation of 3-[(1R,2R))-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol (Tapentadol), or a pharmaceutically acceptable salt thereof, in high yield and purity. Also described are novel intermediates useful for preparing tapentadol or a pharmaceutically acceptable salt thereof.
申请公布号
WO2012146978(A3)
申请公布日期
2013.01.03
申请号
WO2012IB00919
申请日期
2012.04.25
申请人
ACTAVIS GROUP PTC EHF;BONDGE, SANDIPAN, PRABHURAO;KHUNT, MAYUR, DEVJIBHAI;PRADHAN, NITIN, SHARADCHANDRA