| 摘要 |
The invention provides small molecule modulators of retinoic acid receptor-related orphan receptors such as RORa, RORß, or ROR?. Compounds of the invention can be effective modulators at concentrations ineffective to act on LXR receptors, or on other nuclear receptors, or other biological targets. Methods of modulation the RORs and methods of treating metabolic disorders, immune disorders, cancer, and CNS disorders wherein modulation of an ROR is medically indicated are also provided. |
| 申请人 |
THE SCRIPPS RESEARCH INSTITUTE;KAMENECKA, THEODORE MARK;GRIFFIN, PATRICK R.;SHIN, YOUSEUNG;HE, YUANJUN;BLAYO, ANNE-LAURE;LYDA, BRENT R.;KOENIG, MARCEL;KUMAR, NARESH;BURRIS, THOMAS |
发明人 |
KAMENECKA, THEODORE MARK;GRIFFIN, PATRICK R.;SHIN, YOUSEUNG;HE, YUANJUN;BLAYO, ANNE-LAURE;LYDA, BRENT R.;KOENIG, MARCEL;KUMAR, NARESH;BURRIS, THOMAS |
