发明名称 |
Factor VIIa-(poly)sialic acid conjugate having prolonged in vivo half-life |
摘要 |
The present invention relates to a proteinaceous construct comprising plasmatic or recombinant factor VIIa (F VIIa) or biologically active derivatives thereof, which are bound to a carbohydrate moiety comprising 1-4 sialic acid units, wherein the in vivo half-life of the proteinaceous construct is substantially prolonged in the blood of a mammal, as compared to the in vivo half-life of a FVIIa molecule not bound to a carbohydrate moiety. The invention also provides a method for controlling bleeding in a mammal having a bleeding disorder due to functional defects or deficiencies of FVIIa, FVIII, or FIX. The invention also provides a method for controlling bleeding in a mammal during surgery or trauma. |
申请公布号 |
EP2532369(A3) |
申请公布日期 |
2013.01.02 |
申请号 |
EP20120004951 |
申请日期 |
2007.12.14 |
申请人 |
BAXTER INTERNATIONAL INC;BAXTER HEALTHCARE SA |
发明人 |
TURECEK, PETER;SIEKMANN, JUERGEN;SCHEIFLINGER, FRIEDRICH;CANAVAGGIO, MICHEL |
分类号 |
A61K47/48;A61P7/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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