发明名称 |
PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL AS INHIBITORS OF SGLT |
摘要 |
<p>The present invention is directed to a novel process for the preparation of compounds of Formula I having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney.
wherein Ring A and Ring B are one of the following:
(1) Ring A is an optionally substituted unsaturated monocyclic heterocyclic ring, and Ring B is an optionally substituted unsaturated monocyclic heterocyclic ring, an optionally substituted unsaturated fused heterobicyclic ring, or an optionally substituted benzene ring; or
(2) Ring A is an optionally substituted benzene ring, and Ring B is an optionally substituted unsaturated monocyclic heterocyclic ring, or an optionally substituted unsaturated fused heterobicyclic ring wherein Y is linked to the heterocyclic ring of the fused heterobicyclic ring; or
(3) Ring A is an optionally substituted unsaturated fused heterobicyclic ring, wherein the sugar moiety X-(sugar) and the moiety -Y-(Ring B) are both on the same heterocyclic ring of the fused heterobicyclic ring, and Ring B is an optionally substituted unsaturated monocyclic heterocyclic ring, an optionally substituted unsaturated fused heterobicyclic ring, or an optionally substituted benzene ring;
X is a carbon atom;
Y is -(CH 2 ) n -; wherein n is 1 or 2;
provided that in Ring A, X is part of an unsaturated bond;
or a pharmaceutically acceptable salt or solvate thereof.</p> |
申请公布号 |
EP2346888(B1) |
申请公布日期 |
2013.01.02 |
申请号 |
EP20090736928 |
申请日期 |
2009.10.15 |
申请人 |
JANSSEN PHARMACEUTICA, N.V.;MITSUBISHI TANABE PHARMA CORPORATION |
发明人 |
FILLIERS, WALTER FERDINAND MARIA;BROECKX, RUDY LAURENT MARIA;NIESTE, PATRICK HUBERT J.;HATSUDA, MASANORI;YOSHINAGA, MASAHIKO;YADA, MITSUHIRO;TELEHA, CHRISTOPHER |
分类号 |
C07D309/10;C07C1/00;C07H7/04;C07H13/04 |
主分类号 |
C07D309/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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