发明名称 |
METHOD FOR PREPARING 4-DEMETHYLDAUNORUBICIN |
摘要 |
A method of preparing the anthracyclin carminomycin using a starting material comprising daunorubicin. The method comprises reacting daunorubicin or N-protected daunorubicin with soft Lewis acids for the demethylation of the 4-methoxy group, resulting in a reaction mass. The reaction mass is treated with an aqueous solution of a strong organic acid or a mineral acid. After decomposition of the resulting carminomycin and Lewis acids reactive complex, the reaction mass is extracted using a water insoluble organic solvent. As a result, carminomycin is extracted as a base. |
申请公布号 |
EP1976858(A4) |
申请公布日期 |
2013.01.02 |
申请号 |
EP20060848583 |
申请日期 |
2006.12.13 |
申请人 |
SOLUX CORPORATION |
发明人 |
ZABUDKIN, ALEXANDER;MATVIENKO, VICTOR;MATVEEV, ALEXEY;ITKIN, ALEKSANDR |
分类号 |
C07H15/24;A01N43/04;A61K31/70 |
主分类号 |
C07H15/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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