SUBSTITUTED AMINOTETRAHYDROTHIOPYRANS AND DERIVATIVES THEREOF AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OF DIABETES
摘要
<p>The present invention is directed to novel substituted aminotetrahydrothiopyrans and derivatives thereof of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.</p>
申请公布号
EP2538783(A1)
申请公布日期
2013.01.02
申请号
EP20110745203
申请日期
2011.02.17
申请人
MERCK SHARP & DOHME CORP.
发明人
WILKENING, ROBERT, R.;APGAR, JAMES, M.;BIFTU, TESFAYE;FENG, DANQING;QIAN, XIAOXIA;WEI, LAN