发明名称 |
METHOD FOR PRODUCING GLUCURONIC ACID CONJUGATE USING SACCHAROMYCES CEREVISIAE |
摘要 |
Provided is a new method for producing a glucuronide, having excellent productivity and being replaceable with a method using Saccharomyces pombe, and to provide a new means used in this production method. Disclosed are: a transformed Saccharomyces cerevisiae wherein a gene coding for a UDP-glucose dehydrogenase and a gene coding for a UDP-glucose transferase are inserted in a manner such that said genes can be expressed; a transformed Saccharomyces cerevisiae wherein a gene coding for a cytochrome P450 gene is further inserted in a manner such that said gene can be expressed; and a method for producing a glucaronide that includes culturing transformed Saccharomyces cerevisiae in the presence of glucose and a substance to be conjugated, generating the glucuronide of the aforementioned substance to be conjugated. |
申请公布号 |
EP2540826(A1) |
申请公布日期 |
2013.01.02 |
申请号 |
EP20110747205 |
申请日期 |
2011.02.14 |
申请人 |
TOYAMA PREFECTURE |
发明人 |
IKUSHIRO, SHINICHI;SAKAKI, TOSHIYUKI;YASUDA, KAORI |
分类号 |
C12N15/09;C12N1/19;C12P19/18 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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