发明名称 |
SYNTHETIC HLA BINDING PEPTIDE ANALOGUES AND USES THEREOF |
摘要 |
The present invention provides synthetic peptides comprising at least analogues of a native peptide that specifically bind to HLA A0201 or HLA A0301 molecules on a cell characteristic of a pathophysiologic state, such as a cancer cell, in a mammal. Also provided are pharmaceutical compositions and immunogenic compositions comprising at least the peptide analogue segments or a DNA encoding the same. Also provided are methods of using the synthetic peptides and immunogenic compositions to induce a heteroclitic immune response or to treat a cancer. |
申请公布号 |
EP1708732(B1) |
申请公布日期 |
2013.01.02 |
申请号 |
EP20040812790 |
申请日期 |
2004.11.30 |
申请人 |
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH |
发明人 |
SCHEINBERG, DAVID;PINILLA-IBARZ, JAVIER |
分类号 |
A61K38/08;A61K38/00;A61K45/00;A61K48/00;A61K49/00;C07K7/06;C07K14/47;C07K14/82;C12N15/09;C12P21/06 |
主分类号 |
A61K38/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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