发明名称 |
Diverse lead compound autotaxin inhibitors |
摘要 |
Classes of compounds that exhibit effective inhibition of autotaxin enzymes are provided. Such classes include naphthalenesulfones, phenylsulfones, and certain peptides with unnatural amino acids and exhibit reactivity with autotaxin to ultimately reduce the size of the reactive sites thereon to prevent conversion of lysophosphatidyl choline to lysophophatidic acid. Furthermore, such compounds can be incorporated within delivery forms for human ingestion. As such, these compounds accord an excellent manner of potentially reducing generation of certain cancers attributable to the presence of naturally occurring autotaxin within the human body. Methods of inactivating autotaxin to certain degrees therewith such compounds are encompassed within invention as well.
|
申请公布号 |
US8343934(B2) |
申请公布日期 |
2013.01.01 |
申请号 |
US20100828053 |
申请日期 |
2010.06.30 |
申请人 |
UNIVERSITY OF MEMPHIS;PARRILL-BAKER ABBY LOUISE;BAKER DANIEL LEE;NORTH ELTON JEFFREY |
发明人 |
PARRILL-BAKER ABBY LOUISE;BAKER DANIEL LEE;NORTH ELTON JEFFREY |
分类号 |
A61K31/655;C07C245/10;C07C309/52 |
主分类号 |
A61K31/655 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|