发明名称 |
METHOD AND COMPOSITIONS FOR EVALUATING RISK OF DEVELOPING TYPE 2 DIABETES IN PEOPLE OF CHINESE DESCENT |
摘要 |
Methods and compositions for identifying mutations and polymorphisms in mutant genes encoding gene product involved in insulin secretion, for example, hepatocyte nuclear factor-1∝, glucokinase, amylin and mitochondrial DNA are disclosed. Specifically, a microchip comprising a combination of at least two different mutant genes wherein each gene comprises at least one mutation indicative of a predisposition for type-2 diabetes in a member of a Chinese population is disclosed. A kit comprising the microchip, an isolated nucleic acid, primers and probes which are specifically used to screen or identify the mutations in genes of hepatocyte nuclear factor-1∝, glucokinase, amylin and mitochondrial DNA are also disclosed. |
申请公布号 |
HK1065073(A1) |
申请公布日期 |
2012.12.28 |
申请号 |
HK20040107925 |
申请日期 |
2004.10.14 |
申请人 |
THE CHINESE UNIVERSITY OF HONG KONG |
发明人 |
CRITCHLEY, JULIAN A. J. H.;NG, MAGGIE C. Y. NG;LEE, SHAO C.;COCKRAM, CLIVE S.;CHAN, JULIANA C. N. |
分类号 |
C07H;C07K;C07K14/47;C07K14/575;C12N9/12;C12Q;C12Q1/68 |
主分类号 |
C07H |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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