| 发明名称 |
MTP INHIBITING TETRAHYDRO-NAPHTHALENE-1-CARBOXYLIC ACID DERIVATIVES |
| 摘要 |
The present invention is concerned with novel tetrahydro-naphthalene-1-carboxylic acid derivatives having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of atherosclerosis, pancreatitis, obesity, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes. |
| 申请公布号 |
EA017376(B1) |
申请公布日期 |
2012.12.28 |
| 申请号 |
EA20090070399 |
申请日期 |
2007.10.22 |
| 申请人 |
JANSSEN PHARMACEUTICA NV |
发明人 |
MEERPOEL LIEVEN;BACKX LEO, JACOBUS, JOSEF;TEN HOLTE PETER;BUSSCHER GUUSKE, FREDERIKE |
| 分类号 |
C07C235/52;A61K31/216;A61K31/40;A61K31/4025;A61K31/5377;A61K31/55;C07C231/02;C07C231/16;C07C233/57;C07C233/78;C07C235/54;C07C235/60;C07D207/14;C07D223/12;C07D265/30 |
主分类号 |
C07C235/52 |
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