| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: present invention refers to a new (-)-stereoisomer of formula(I) wherein X is H, or its pharmaceutically acceptable salt which agonise GABA receptor, to a pharmaceutical composition on the basis of the presented compound, to a method for preparing the (-)-stereoisomer of formula (I) or its pharmaceutically acceptable salt, to a method for inducing or maintaining general anaesthesia, to a method for promoting pain management and to a method for promoting pain management and to a method for prototyping antiemetic activity with the use of the presented (-)-stereoisomer or its pharmaceutically acceptable salt, as well as to a new diastereoisomer (-)-2,6-di-fluoro-butylphenyl ester of carbamic acid of formula(II) wherein Rrepresents a chiral amino group, and X is H, or to its pharmaceutically acceptable salt.EFFECT: preparing the pharmaceutically acceptable salt which agonise GABA receptor.14 cl, 15 ex, 8 tbl, 3 dwg |
