发明名称 |
USE OF PLATELET ACTIVATING FACTOR ACETYLHYDROLASE AS A BIOMARKER FOR ANAPHYLAXIS |
摘要 |
The invention provides a use of platelet activating factor acetylhydrolase (PAF-AH) activity as a biomarker for severe or fatal anaphylaxis in a subject. The level of PAF-AH activity inversely correlates with the susceptibility to severe or fatal anaphylaxis. The use comprises assaying PAF-AH activity in a sample from the subject and comparing the measured activity to a reference value, wherein a lower level of measured PAF-AH activity relative to said reference level of PAF-AH activity indicates a presence of or susceptibility to severe or fatal anaphylaxis in the subject. A method for treating or preventing severe or fatal anaphylaxis in a subject is also provided. The method comprises increasing serum platelet activating factor acetylhydrolase (PAF-AH) concentration in the subject by administering to the subject, PAF-AH and/or a PAF receptor antagonist. A composition for treating severe or fatal anaphylaxis is also provided.
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申请公布号 |
US2012328596(A1) |
申请公布日期 |
2012.12.27 |
申请号 |
US201213602289 |
申请日期 |
2012.09.03 |
申请人 |
VADAS PETER;ALLERTECH LABORATORY INC. |
发明人 |
VADAS PETER |
分类号 |
G01N21/76;A61K38/46;A61P11/00;C12N9/18 |
主分类号 |
G01N21/76 |
代理机构 |
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主权项 |
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地址 |
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